Analysis of the proteome data involving 109 HNSCC patients revealed a significant positive correlation between CD109 and NRF2 expression and NRF2 functional pathway, while querying the genomic data comprising 523 HNSCC patients showed a clinically relevant positive correlation between CD109 expression and the expression of IL6Rα, NRF2 and a large number of NRF2 target genes. This evidence concerns the gene IL6R and head and neck squamous cell carcinoma.