SIRT2 and brucellosis: In summary, this study investigated the impact of SIRT2 on the intracellular survival of Brucella and Brucella-induced mitochondrial apoptosis in trophoblast cells, revealing the role of SIRT2 in the pathogenic mechanism of Brucella. These findings provide a theoretical basis for exploring effective host-directed therapies for brucellosis, offering new insights into how Brucella evades immune clearance through host cell regulatory mechanisms.