In vivo, the up-regulation of IL-33 and ST2 expression early after DAC administration (i.e., 3 days) was associated with up-regulation of T cell-attracting chemokines CCL5, CCL11, CXCL9 and the eosinophil-attracting chemokine CCL11, and accumulation of CD4-T, CD8-T cells and eosinophils in the TME of WT but not in ST2−/− tumor-bearing mice. The gene discussed is CD4; the disease is neoplasm.