The m6A “writers” METTL3 and m6A “readers” IGF2BP2/3 were found to participate in the methylation of VEGFA to prevent mRNA degradation, and to promote angiogenesis in colorectal cancer by mimicking the formation of the PI3K/AKT/mTOR and ERK1/2 signaling pathways [28]. This evidence concerns the gene AKT1 and colorectal cancer.