Our results demonstrated that knockdown of USP5, USP7, USP8, USP14, USP19, USP21 led to a significant reduction in TOM22 expression in the LoVo CRC cell line, while knockdown of PSMD14 and UCHL5 led to a significant increase (Fig. 1b–d). This evidence concerns the gene USP21 and colorectal carcinoma.