RHO and viral infectious disease: The Rho-PAK signaling axis represents another important pathway in viral infection, regulating cellular migration, adhesion, and proliferation through the phosphorylation of downstream substrates including v-crk sarcoma virus CT10 oncogene homolog (Crk) and Crk SH3 domain-binding guanine nucleotide exchange factor (C3G) [79, 80].