Canonical pathways identified by IPA include the role of osteoclasts in rheumatoid arthritis signaling, GP6 signaling, GPVI-mediated activation cascade, wound healing signaling, Rho GTPase cycle, signaling by Rho family GTPases, and G-protein coupled receptor signaling, and others (S file 4 ‘4 moTI vs 4 moPI – Canonical Pathways). This evidence concerns the gene GP6 and rheumatoid arthritis.