Multivariate analysis of OS revealed ‘lymph node metastasis’ (HR, 4.71; 95% CI 1.75–12.7; p = 0.002), ‘ER negative’ (HR, 7.92; 95% CI 1.01–61.8; p = 0.048), and ‘low ATP7B expression’ (HR, 2.38; 95% CI 1.02–5.57; p = 0.046) as independent prognostic factors (Table S2). The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.