Multivariate analysis of DFS revealed ‘lymph node metastasis’ (HR, 3.56; 95% CI 1.42–8.92; p = 0.007) and ‘low ATP7B expression’ (HR, 2.82; 95% CI 1.15–6.92; p = 0.024) as independent prognostic factors (Table 3). This evidence concerns the gene ATP7B and metastatic malignant neoplasm in the lymph nodes.