Since MEFV gene mutations are known to be associated with activation of the interleukin (IL)- 1β pathway, they have been investigated in inflammatory diseases in including Behçet’s disease, Crohn’s disease, ulcerative colitis and Immunoglobulin A vasculitis, and found to be associated with disease severity [16–19]. The gene discussed is MEFV; the disease is Behcet disease.