Possibly reflecting an infarct-related process, we note that some proteins (e.g. NfL, BCAN, CLEC10A, CNTN5, GDF-8, GPC5, HAGH, and SPOCK1) were associated to cognitive outcome when measured in the acute or convalescent stroke phase, but not in the adjusted cross-sectional analyses at the 7-year follow-up in our study. This evidence concerns the gene SPOCK1 and stroke disorder.