Focusing on 14-3-3ζ which was reported to be highly expressed in various cancers [6–8], we found that BA also inhibited the binding of 14-3-3ζ to TSC2, Rictor, Raptor, mTOR, FOXO1, FOXO3a, and STAT3 (Fig. 2f). The gene discussed is STAT3; the disease is cancer.