E2F2 has been implicated in regulation of cancer stem cell (CSC) properties by various microRNAs [29–31] and necessary for self-renewal of stem cells and radioresistance of glioblastoma [32], whereas E2F8 is thought to be associated with tumorigenesis and radioresistance [33] as well as with EMT [34]. This evidence concerns the gene E2F2 and cancer.