When analysed by extent of metastasis, MTC and m-MTC thyroid tissue was found to contain significantly less GSK3β than CCH tissue across the whole cell (Fig. 4d), and less cytoplasmic GSK3β than both histologically normal thyroid tissue and CCH tissue (Supplementary Fig. 4e). The gene discussed is GSK3B; the disease is columnar cell hyperplasia of the breast.