Since AD postmortem brain tissues contain proteopathic seeds, including Aβ and tau, that have the prion-like seeding activity to induce the counterpart normal protein to aggregate in animal models [42–46], we hypothesize that sAD postmortem tissue-derived brain extracts that contain both Aβ and tau seeds, can induce multiple AD pathologies in human cells in organoids, mirroring observations in sAD. The gene discussed is MAPT; the disease is Alzheimer disease.