Contrary to sPD-1, the median level of sTIM-3, LAG-3 and Gal-3 in plasma were shown to be similar in all groups of patients (F0/1, F2, F3, F2 + F3), which indicates their limited involvement in the immunopathogenesis of LF as well as potential as markers of LF stage of in the course of CHC. This evidence concerns the gene HOXD13 and Lassa fever.