Contrary to sPD-1, the median level of sTIM-3, LAG-3 and Gal-3 in plasma were shown to be similar in all groups of patients (F0/1, F2, F3, F2 + F3), which indicates their limited involvement in the immunopathogenesis of LF as well as potential as markers of LF stage of in the course of CHC. The gene discussed is HOXD13; the disease is cryohydrocytosis.