Several of the strong signalling pathway detections are also related to immune system, as ‘RIG-I-like receptor signaling pathway’ works in defence against virus infections, ‘Rap1 signaling pathway’ has been shown to regulate T cell response35, and ‘IL-17 signaling pathway’ recruits immune cells to the site of inflammation and it has been linked to different autoimmune diseases36. Here, IL17A is linked to viral infectious disease.