Research has proposed that circ-SIRT1 can promote autophagy in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and H9c2 cardiomyocytes by activating SIRT1, thus mitigating Ang II-induced cardiac hypertrophy (CH), based on the finding that autophagy deficiency leads to CH [28]. Here, SIRT1 is linked to cardiac hypertrophy.