Genes such as SHBG, SERPINF2, PRPF8, PRMT6, BRI3, BAIAP2L1, NF1, BMP8A, PABPC4, TUFM, PPIF, SULT1A1, NYNRIN and RP11-327J17.2 have significant shared colocalization signal with total testosterone levels, SHBG levels, or hypogonadism (Supplementary Data 3). The gene discussed is TUFM; the disease is hypogonadism.