Considering this relationship, we evaluated whether high expression levels of both Snord67 and CKAP5 would be associated with a greater effect on survival, and we observed that HER2-enriched breast cancer patients with high Snord67 and high CKAP5 expressing tumors had markedly decreased overall survival compared to patients with low Snord67 and low CKAP5 expressing tumors (Supplemental Fig. 12G). The gene discussed is CKAP5; the disease is breast carcinoma.