To replicate these findings in a human breast cancer model, we generated a Snord67 knockout clone in MDA-MB-231-D3H2LN-luc (D3H2), a cell line that spontaneously metastasizes to loco-regional lymph nodes and was derived from the human triple-negative breast adenocarcinoma model MDA-MB-23133. The gene discussed is SNORD67; the disease is breast carcinoma.