The literature included herein showed a significant increase in complement effector proteins (Bb, C3b, C1q, C4b, C5b, C5b-C9 TCC, and Factor D) and a significant decrease in complement regulatory proteins (DAF, CD46, CD59, and CR1) in plasma NDsEVs and ADsEVs of patients with AD, which had moderate diagnostic value when used independently. This evidence concerns the gene CD59 and Alzheimer disease.