GRIN2A and Alzheimer disease: This aligns with the changes observed in synaptic protein content in brain tissue from other studies, in which neurogranin [88], synaptotagmin [89], synaptopodin [90], and synaptophysin [[91], [92], [93]–94] were significantly reduced in the brain tissue of both patients with AD and AD model mice, while NMDAR2A levels decreased [95].