The literature included herein showed a significant increase in complement effector proteins (Bb, C3b, C1q, C4b, C5b, C5b-C9 TCC, and Factor D) and a significant decrease in complement regulatory proteins (DAF, CD46, CD59, and CR1) in plasma NDsEVs and ADsEVs of patients with AD, which had moderate diagnostic value when used independently. The gene discussed is CR1; the disease is Alzheimer disease.