IFNG and tuberculosis: Current tests are based on quantifying the cell-mediated immune response using either skin induration from tuberculin skin testing (TST) or ex vivo interferon-γ (IFN-γ) reactivity to Mtb-specific antigens by IFN-γ release assays (IGRA).8 LTBI, encompassing individuals who are Mtb-sensitized, therefore may represent diverse immune responses to tuberculosis including eliminated, controlled or subclinical infection.1,2 How these immune states relate to glucose metabolism, including diabetes risk, has not been addressed.