IL6 and osteosarcoma: Considering multiple studies indicating that ICAM1 expression can be induced by IL-6, which can even promote its gene expression in endothelial cells and human osteosarcoma cells,39,40 the lower amounts of IL-6 in USSCs may contribute to the reduction in ICAM1. It can be concluded that improving the expression status of both genes is achievable through alterations in oxygen conditions.