Considering multiple studies indicating that ICAM1 expression can be induced by IL-6, which can even promote its gene expression in endothelial cells and human osteosarcoma cells,39,40 the lower amounts of IL-6 in USSCs may contribute to the reduction in ICAM1. It can be concluded that improving the expression status of both genes is achievable through alterations in oxygen conditions. Here, ICAM1 is linked to osteosarcoma.