Type 2 diabetes onset is associated with a wide range of genetic, lifestyle, and environmental factors.2 Adiposity is a well-established risk factor for developing T2D through mechanisms including β-cell dysfunction and reduced insulin production.3 However, a meta-analysis4 and a cross-biobank analysis5 demonstrated that genetic predisposition to obesity was associated with the development of T2D, even after adjustment for body mass index (BMI)—suggesting that other mechanisms play a role. Here, INS is linked to type 2 diabetes mellitus.