MSLN and neoplasm: Last, we detailed the single-cell transcriptional profiles of iNK-treated and untreated tumors, as well as of tumor-infiltrating MSLN.CAR-IL-15 iNK cells, which uncovered the early responses of MSLN-positive tumor cells to iNK cell–mediated killing and provided a comprehensive analysis of characteristics of MSLN.CAR-IL-15 iNK cells adapting to the solid tumor context.