TNF and neoplasm: The pathway enrichment analysis revealed the pathways significantly enriched in tumor-infiltrating NK cells versus preinfusion NK cells, including TNF-α signaling via NF-κB, hypoxia, interferon-γ response, interferon-α response, apoptosis, heme metabolism, IL-2-STAT5 (signal transducers and activators of transcription 5) signaling, estrogen response, and p53 pathway (Fig. 8D).