Tumor-infiltrating clusters NK1 and NK5 showed high expression of NK-activating receptors, including NKG2D-DAP10 (KLRK1/HCST), NKG2C (KLRC2), CD94 (KLRD1), and NKp30 (NCR3), suggesting that they were robustly activated. This evidence concerns the gene KLRD1 and neoplasm.