Through unsupervised clustering, seven tumor clusters (11,501 cells) and seven NK clusters (11,786 cells) were classified (Fig. 7A) on the basis of the respective canonical marker genes of mesothelioma (MSLN, KRT8, and KRT18) and NK cells [PTPRC, NCAM1, NKG7, and hYP218 (CAR)] (Fig. 7B), as well as top marker genes (up to 100) expressed in each cluster (data S1). The gene discussed is KRT18; the disease is neoplasm.