However, studies suggest that the P2RX7-NLRP3 complex regulates αSyn levels in neural mononuclear cells of Parkinson’s patients, while interactions between extracellular αSyn and P2RX7 may induce mitochondrial dysfunction, oxidative stress, and αSyn structural changes, promoting aggregation [12,67]. The gene discussed is NLRP3; the disease is Parkinson disease.