High mitotic and Mib1 proliferative indices were also correlated to lower OS (55 months versus 184, p < 0,0001 and 70 months versus 184, p < 0,0001 respectively) with vascular proliferation (81 versus 193 months, p < 0,0001) and tumor necrosis (60 versus 184 months, p < 0,0001): Table 2 and Fig 4. Here, MIB1 is linked to neoplasm.