Genomic analysis of large cohorts of gliomas have also highlighted the prognostic value of PIK3CA mutation [8–10], TCF12 mutation [8,11] and MYC pathway deregulation (by gene locus gain or gene promoter hypomethylation or by downregulation of MYC silencers [12] which appear to be linked to unfavorable outcome in O3. The gene discussed is MYC; the disease is central nervous system cancer.