CD8A and neoplasm: In mice bearing A20 tumors, there was evidence of anti-tumor activity despite depletion of NK cells, CD8 T cells, or CD4 T cells (growth rate inhibition (GRI) of 31% (P = 0.017), 37% (P = 0.002), or 42% (P = 0.098), respectively, versus their respective vehicle control; Fig 5A–C).