TNFRSF1B and Cachexia: [72,73] In support of this finding, cachexia related blood biomarkers such as interleukine-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), soluble tumor necrosis factor receptor II (TNF-RII) and branched-chain amino acids (BCAAs) are associated with greater muscle loss.