The parent gene, Aff3, is located in a genetically variable region, and it can be excised via intron 5 to form a replicable transposon that translocates to other chromosomes, potentially contributing to leukemia (Chinen et al., 2008; Hiwatari et al., 2003; Miller et al., 2022; Bergh et al., 2002). Here, AFF3 is linked to leukemia.