APOE and atherosclerosis: Using three mouse models (global Aff3ir-ORF2 knockout, locally Aff3ir-ORF2 endothelial expression, and endothelial-specific Aff3ir-ORF2 overexpression), we demonstrated that Aff3ir-ORF2 exerted potent anti-inflammatory and anti-atherosclerosis effects in Apoe-/- mice.