In sharp contrast, the expression of ADan fusion leads to 25.14 ± 3.41% of the cells growing in selection media over nonselective conditions, a twofold increase compared to the growth rate induced in the same conditions by the amyloid-beta peptide (Aβ42), the peptide that forms amyloids in Alzheimer’s disease and is mutated in familial forms of the disease (16) (Fig. 1C and SI Appendix, Fig. S1B). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.