C9orf72 and amyotrophic lateral sclerosis: An evaluation of CT profiles of this region has revealed a different preferential involvement of specific areas in variant carriers ALS patients or in subjects with a cognitive disruption, with only some cerebellar regions (i.e., lobules I–V of the anterior lobe in patients with sporadic ALS or posterior lobe and vermis in C9orf72 mutation carriers) apparently spared by this thinning [52, 69, 70].