In terms of ApoE4 levels, significant differences were detected between AD and CBS-Aβ(–) (p = 0.003) and AD and HC (p = 0.002), but CBS-Aβ(–) and HC showed no significant differences (p > 0.05). However, as shown in Table 3, a markedly higher proportion of ApoEε4 carriers was found in the AD group compared to CBS-Aβ( +) and CBS-Aβ(–), where the number of ApoEε4 carriers was notably lower. This evidence concerns the gene APOE and Alzheimer disease.