Curcumin can regulate the NF-κB (nuclear factor kappa-B), JAK/STAT (Janus kinase/signal transducer and activator of transcription), and PI3K/AKT/mTOR (phosphoinositide-3-kinase/protein kinase B/mechanistic target of rapamycin) pathways, which are involved in ALI. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.