The mechanism underpinning the protumorigenic effect of TAMs potentially involves suppression of antitumor functionality by transforming growth factor-beta (TGF-β), promoting migration, and recruiting a substantial number of TAMs within the tumor milieu, thereby promoting progression of the tumor via activation of the CXCL8-CXCR1/2 signaling axis [58]. Here, CXCR1 is linked to neoplasm.