CD8A and neoplasm: Based on the heterogeneous spatial distribution of CD8+ T cells, the TIME can be categorized into the following three immunophenotypes: an immunodeficiency type, characterized by a low number of lymphocytes in and around the tumor; an immunosuppressive type, with evident peritumoral infiltration, but a small number of intratumor lymphocytes, indicating limited lymphocyte infiltration into the tumor stroma; and an immunoinflammatory type, characterized by extensive lymphocyte infiltration within the tumor [13].