In experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, IL-7 directly promotes the expansion of pathogenic TH17 cells, while IL-7R antagonism induces apoptosis in these cells by inhibiting the JAK-STAT5 pathway and altering the expression of pro-survival and pro-apoptotic proteins (95). The gene discussed is IL7; the disease is myeloid sarcoma.