ICOS and infection: In keeping with our findings for H1, there was a trend for a lower risk of grade ≥3 infection in patients with a greater proportion (25th centile or higher; ≥ 0.072%) of ICOS+HLA-DR+PD1+TIGIT+Tbet+ Th cells (HR 0.358 [95% CI: 0.109 – 1.186], P = 0.076; Figure 2E).