Three markers, CD40L (622 vs. 1068 pg/ml), E-cadherin (28061 vs. 54583 pg/ml), and soluble Gal-1 (4304 vs. 5221 pg/ml) decreased significantly in the plasma of peripheral blood of AML patients vs. HCs (Supplementary Figure 19). The gene discussed is CD40LG; the disease is acute myeloid leukemia.