Six soluble mediators of the 31 in the panel showed significantly increased concentrations in AML vs. HCs: the BAFF (6482 vs. 569 pg/ml), B7-H2 (5849 vs. 2537 pg/ml), B7-H4 (437 vs. 292 pg/ml), CD25 (1547 vs. 656 pg/ml), MICA (30.9 vs. 20.1 pg/ml), and Siglec-7 (5.1 vs. 3.3 pg/ml). Here, MICA is linked to acute myeloid leukemia.