Transforming growth factor beta 1 (TGFB1) belongs to the TGF-β subfamily and the TGF-β signaling pathway, which regulates cell fate and plays pleiotropic roles in tumor malignant progression by regulating cell proliferation, apoptosis, migration, and tumor microenvironment (TME) (19, 20). The gene discussed is TGFB1; the disease is neoplasm.