PTX3 and cystic fibrosis: Moalli F et al.demonstrated that PTX3 reduces lung infections in mice by decreasing levels of pro-inflammatory cytokines (e.g.,IL-1β) and chemokines (e.g., CXCL1, CXCL2, and CCL2), as well as by reducing airway neutrophil recruitment in a mouse model infected with the clinical strain RP73, isolated from CF patients (41).