The IVW model demonstrated that higher levels of HLA-DR on plasmacytoid dendritic cells (DCs) (OR = 1.147, 95% CI: 1.058–1.243, p = 0.001), CD27 on CD20− CD38− B cells (OR = 1.127, 95% CI: 1.058–1.243, p = 0.010), CD80 on myeloid DCs (OR = 1.086, 95% CI: 1.015–1.163, p = 0.016), memory B cell AC (OR = 1.059, 95% CI: 1.004–1.111, p = 0.020), and CD8dim T cell %T cell (OR = 1.131, 95% CI: 1.014–1.251, p = 0.025) were associated with an increased risk of developing OM. The gene discussed is CD27; the disease is ocular melanoma.