Prdx6 can slow down cell ferroptosis through a variety of mechanisms, including reducing intracellular free iron ions to inhibit Fenton chemical reaction, maintaining mitochondrial function to reduce mitochondrial damage, directly reducing the level of lipid peroxidation products, and increasing the level of selenoprotein, so as to delay the progression of metabolic diseases. The gene discussed is PRDX6; the disease is metabolic disease.