Mechanotransduction and Heart Failure: Mechanosensitive TRP channels (e.g., TRPC6 (Onohara et al., 2006), TRPM7 (Yu et al., 2014), TRPV4 (Veteto et al., 2020)) are activated under pathological stretch, making them promising targets in heart failure. This evidence concerns the gene TRPM7 and heart failure.