SAMHD1 and cancer: Sterile alpha motif and HD domain-containing protein1 (SAMHD1)is a metal-dependent hydrolase that plays key roles in dNTP homeostasis,antiretroviral defense, and regulation of various cancers in humans.Beyond mammals, SAMHD1 is also present in a wide range of eukaryotes,including invertebrates, plants, and human parasites.