PRRX2 and myocardial infarction: PRRX2 is a transcription factor involved in vascular smooth muscle cell differentiation and migration, with established roles in cardiovascular development during embryogenesis.38 A recent study linked the upregulation of PRRX2 signaling to cardiac remodeling post-myocardial infarction in a mouse model, indicating its potential involvement in SBP and CIMT through arterial vascular smooth muscle cell proliferation or remodeling.