MYH14 and atrial fibrillation: By what mechanism this occurs is not known, however it has been recently found that propofol can bind to the Ryanodine Receptor in skeletal muscle (76), and it directly interacts with myosin, actin, and myosin light chain protein (77) and induces a decrease in Tmax (63, 77, 78)--the same parameter we saw increased in AF.