Multiple groups have identified spatial learning and memory deficits induced by CIH based on reductions in behavioral performance, postsynaptic density and long-term potentiation in the hippocampus in two separate AD model paradigms: APP/PS1 mice after 2-weeks of CIH treatment and a tau mouse model after 8-weeks of CIH exposure [67, 68]. The gene discussed is APP; the disease is Alzheimer disease.