The signature titled Liu_Hypoxia had the poorest prognostication for Ectoderm and Endoderm derived malignancies (Figs. 3A and 3B).23 The Oliveira proliferating T-cell gene signature (Oliveira_Prolif_T) and Caushi proliferating CD8 T-cell signature (Caushi.CD8.Proliferating) correlated with shorter PFI and OS respectively within the mesoderm-derived malignancies (Fig. 3C).9, 10 Of these TIL-immune signatures, 10.6% (n = 18/170) of their genes were shared amongst two of these signatures, however, no gene was shared across all 3 signatures associated with poor OS and PFI. Here, CD8A is linked to cancer.