Although the original hypothesis of tumor recognition did not seem apparent, our data did frequently identify signatures expressing genes associated with a “less exhausted” cell phenotype as top prognosticators of OS and PFI (Caushi.stem-like memory, Caushi.CD8.Stem-like memory, B16_Prog.Ex_Miller, Jansen_Stem like, Krishna.ACT.CD8.Stem.Like, LCMV_Prog.EX_Miller).9, 25, 28, 31 Many of these signatures feature genes associated with more “stem-like” phenotype (IL7R, TCF7, SELL, CCR7, etc) (Table 6). This evidence concerns the gene CD8A and neoplasm.