Across our 146 gene signatures, the Zhang CD8 T-Cell associated gene signature for prognosis risk in lung adenocarcinoma (Zhang CD8 TCS) appeared to have the lowest OS and PFI coefficients, consistent with the strongest association with longer OS and PFI (Fig. 2A, Supplemental Table 3).16 Alternatively, the Liu hypoxia-associated gene score in bladder cancer (Liu_Hypoxia) appeared to have the highest OS and PFI coefficients, consistent with an association with shorter OS and PFI (Fig. 2A).1 This evidence concerns the gene CD8A and urinary bladder carcinoma.