Despite this variability, two signatures were found to correlate with OS coefficient across multiple cancer types, the Tang ferroptosis related gene signature in head and neck squamous cell carcinoma (Tang_Ferroptosis) and Zhang.CD8.TCS, each seen across 4 cancer types (BLCA, CESC, HNSC, SARC and ACC, KIRC, LUAD, PCPG) (Fig. 4A, Table 3).15, 16. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.