EDNRA and systemic lupus erythematosus: In females, anti-ETAR autoantibodies were significantly elevated in both SLE non-HTN and SLE-HTN subjects compared to non-SLE HTN (p = 0.0125 and p = 0.0006, respectively) and non-SLE non-HTN subjects (p < 0.0001 for both comparisons; Fig. 2E and Supplemental Table 11).