Both compounds inhibited breast cancer cell growth and induced apoptosis and there was a concordance between the effects of NR4A1 and NR4A2 knockdown and effects of DIM-3,5 analogs in MDA-MB-231 cells and on several NR4A-regulated genes including EGFR, β1-integrin, bcl-2 and c-Myc. This evidence concerns the gene NR4A2 and breast cancer.