This hypothesis was based on previous reports showing that several natural products including polyphenolic such as quercetin, tetrandrine and resveratrol all induce ferroptosis in cancer cells [24–29] and studies in this laboratory show that these compounds also bind NR4A1 and exhibit inverse NR4A1 agonist activity [30–33] similar to that observed for DIM-3,5 analogs [18]. The gene discussed is NR4A1; the disease is cancer.