DIM-3,5-CI2 and DIM-3-CI-5-CF3 were recently characterized as ligands that bind both NR4A1 and NR4A2 and inhibit NR4A1/NR4A2-dependent genes and pathways in cancer cells [18, 19, 47] and this was confirmed in TNBC cells as illustrated in Fig. 1. Here, NR4A2 is linked to cancer.