HGF and neoplasm: Given the strong effect of ectopic HGF expression in vivo (Fig. 2A) and the ability of fibroblast-produced HGF to provide ALKi protection in vitro (Fig. 1), we reasoned that the modest effect of stromal hHGF in xenograft models could reflect the spatial limitations, as cMET activation can be expected to be limited to tumor cells in the immediate proximity to hHGF-producing stroma.