Neurological manifestations including microcephaly, developmental delay, intellectual disability, speech delay and infantile hypotonia, have been reported in CAKUT patients carrying heterozygous nonsense or frameshift mutations of ZMYM2. In X. tropicalis, Zmym2 knockdown of leads to craniofacial defects. The gene discussed is ZMYM2; the disease is congenital anomaly of kidney and urinary tract.